Rescue of severe brain and cervical cord IRIS by restarting natalizumab in a pregnant MS patient

نویسندگان

  • Thomas H. Massey
  • Rachel Smith
  • Shaheena Sadiq
  • Christopher Overton
  • Owen R. Pearson
چکیده

Natalizumab inhibits lymphocyte trafficking across the blood–brain barrier, reducing relapse rates by up to 70% in patients with relapsing-remitting multiple sclerosis (RRMS). Discontinuation of the drug, usually due to pregnancy or risk of progressive multifocal leukoencephalopathy (PML), can trigger the return of disease activity or, occasionally, a fulminant immune reconstitution inflammatory syndrome (IRIS) as lymphocytes re-enter the CNS. We describe a case of life-threatening IRIS following natalizumab cessation in pregnancy, but complete clinical rescue with no adverse sequelae following drug restart in the second trimester.

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عنوان ژورنال:

دوره 88  شماره 

صفحات  -

تاریخ انتشار 2017